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تداخل‌های دارویی

Chloramphenicol + Palovarotene

شدت: شدید

Chloramphenicol and Palovarotene: major interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Palovarotene is cleared largely by CYP3A4, and chloramphenicol may increase its concentrations. Retinoid toxicity such as mucocutaneous effects, bone changes and hypervitaminosis A-like effects could be amplified.

معنای این تداخل به زبان ساده

Chloramphenicol and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Chloramphenicol belongs to Anti Bacterial; Palovarotene belongs to Miscellaneous.

سطح شواهد: Low

چرا رخ می‌دهد

Chloramphenicol inhibits CYP3A4 metabolism of palovarotene.

اقدام لازم

Avoid the combination and choose another antibiotic. If it cannot be avoided, monitor closely for retinoid toxicity and consider a dose reduction.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Chloramphenicol و Palovarotene، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Chloramphenicol with Palovarotene?

MediHelp rates the interaction as major. Chloramphenicol and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palovarotene is cleared largely by CYP3A4, and chloramphenicol may increase its concentrations. Retinoid toxicity such as mucocutaneous effects, bone changes and hypervitaminosis A-like effects could be amplified.

How serious is the interaction between Chloramphenicol and Palovarotene?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If it cannot be avoided, monitor closely for retinoid toxicity and consider a dose reduction.

What other medicines interact with Chloramphenicol?

MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.

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