Drug interactions
Chloramphenicol + Palovarotene
Severity: Major
Chloramphenicol and Palovarotene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is cleared largely by CYP3A4, and chloramphenicol may increase its concentrations. Retinoid toxicity such as mucocutaneous effects, bone changes and hypervitaminosis A-like effects could be amplified.
What this interaction means in plain words
Chloramphenicol and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Palovarotene belongs to Miscellaneous.
Why it happens
Chloramphenicol inhibits CYP3A4 metabolism of palovarotene.
What to do
Avoid the combination and choose another antibiotic. If it cannot be avoided, monitor closely for retinoid toxicity and consider a dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Chloramphenicol with Palovarotene?
MediHelp rates the interaction as major. Chloramphenicol and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palovarotene is cleared largely by CYP3A4, and chloramphenicol may increase its concentrations. Retinoid toxicity such as mucocutaneous effects, bone changes and hypervitaminosis A-like effects could be amplified.
How serious is the interaction between Chloramphenicol and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If it cannot be avoided, monitor closely for retinoid toxicity and consider a dose reduction.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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