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تداخل‌های دارویی

Clarithromycin + Duvelisib

شدت: شدید

Clarithromycin and Duvelisib: major interaction.

آخرین به‌روزرسانی

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خلاصه

Clarithromycin significantly raises duvelisib exposure, increasing the risk of serious infections, diarrhea or colitis, cutaneous reactions and pneumonitis. Duvelisib may also inhibit CYP3A4 and raise clarithromycin levels.

معنای این تداخل به زبان ساده

Clarithromycin and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Duvelisib belongs to Oncology.

سطح شواهد: High

چرا رخ می‌دهد

Clarithromycin is a strong CYP3A4 inhibitor that reduces duvelisib metabolism; duvelisib is itself a CYP3A4 inhibitor.

اقدام لازم

Reduce duvelisib to 15 mg twice daily during the combination, as labeled. Monitor for toxicity, or use a non-CYP3A4-inhibiting antibiotic.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Duvelisib، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Clarithromycin with Duvelisib?

MediHelp rates the interaction as major. Clarithromycin and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin significantly raises duvelisib exposure, increasing the risk of serious infections, diarrhea or colitis, cutaneous reactions and pneumonitis. Duvelisib may also inhibit CYP3A4 and raise clarithromycin levels.

How serious is the interaction between Clarithromycin and Duvelisib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce duvelisib to 15 mg twice daily during the combination, as labeled. Monitor for toxicity, or use a non-CYP3A4-inhibiting antibiotic.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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