تداخل‌های دارویی
Duvelisib + Ergotamine
شدت: منع مصرف
Duvelisib and Ergotamine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Ergotamine is cleared mainly by CYP3A4, and higher levels carry a risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
معنای این تداخل به زبان ساده
Duvelisib and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duvelisib belongs to Oncology; Ergotamine belongs to Central Nervous System.
چرا رخ می‌دهد
Duvelisib inhibits CYP3A4, reducing the first-pass and systemic metabolism of ergotamine.
اقدام لازم
Avoid combining ergotamine with duvelisib and choose a non-ergot acute migraine treatment. If it cannot be avoided, monitor closely for ischemic symptoms such as cold or numb extremities and chest pain.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Duvelisib و Ergotamine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Ergotamine
- Almotriptan + Ergotamine منع مصرف
- Atazanavir + Ergotamine منع مصرف
- Clarithromycin + Ergotamine منع مصرف
- Cobicistat + Ergotamine منع مصرف
- Darunavir + Ergotamine منع مصرف
- Dihydroergotamine intranasal + Ergotamine منع مصرف
تداخلات دیگر Duvelisib
پرسش‌های متداول
Can I take Duvelisib with Ergotamine?
MediHelp rates the interaction as contraindicated. Duvelisib and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Ergotamine is cleared mainly by CYP3A4, and higher levels carry a risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Duvelisib and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining ergotamine with duvelisib and choose a non-ergot acute migraine treatment. If it cannot be avoided, monitor closely for ischemic symptoms such as cold or numb extremities and chest pain.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
