تداخلهای دارویی
Clarithromycin + Elacestrant
شدت: شدید
Clarithromycin and Elacestrant: major interaction.
آخرین بهروزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Strong CYP3A4 inhibitors increase elacestrant exposure and may worsen its adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding concomitant use with strong or moderate CYP3A4 inhibitors.
معنای این تداخل به زبان ساده
Clarithromycin and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Elacestrant belongs to Oncology.
چرا رخ میدهد
Clarithromycin inhibits CYP3A4, the main metabolic pathway of elacestrant.
اقدام لازم
Avoid the combination and use an antibiotic that does not inhibit CYP3A4, such as azithromycin. If clarithromycin is unavoidable, monitor for elacestrant toxicity.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Clarithromycin و Elacestrant، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Clarithromycin
- Astemizole + Clarithromycin منع مصرف
- Avanafil + Clarithromycin منع مصرف
- Cisapride + Clarithromycin منع مصرف
- Clarithromycin + Colchicine منع مصرف
- Clarithromycin + Conivaptan منع مصرف
- Clarithromycin + Dihydroergotamine منع مصرف
تداخلات دیگر Elacestrant
پرسشهای متداول
Can I take Clarithromycin with Elacestrant?
MediHelp rates the interaction as major. Clarithromycin and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors increase elacestrant exposure and may worsen its adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding concomitant use with strong or moderate CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Elacestrant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antibiotic that does not inhibit CYP3A4, such as azithromycin. If clarithromycin is unavoidable, monitor for elacestrant toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
تکنگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.