Drug interactions
Clarithromycin + Elacestrant
Severity: Major
Clarithromycin and Elacestrant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors increase elacestrant exposure and may worsen its adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding concomitant use with strong or moderate CYP3A4 inhibitors.
What this interaction means in plain words
Clarithromycin and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Elacestrant belongs to Oncology.
Why it happens
Clarithromycin inhibits CYP3A4, the main metabolic pathway of elacestrant.
What to do
Avoid the combination and use an antibiotic that does not inhibit CYP3A4, such as azithromycin. If clarithromycin is unavoidable, monitor for elacestrant toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Clarithromycin with Elacestrant?
MediHelp rates the interaction as major. Clarithromycin and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors increase elacestrant exposure and may worsen its adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding concomitant use with strong or moderate CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Elacestrant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antibiotic that does not inhibit CYP3A4, such as azithromycin. If clarithromycin is unavoidable, monitor for elacestrant toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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