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تداخل‌های دارویی

Clarithromycin + Eplerenone

شدت: منع مصرف

Clarithromycin and Eplerenone: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Clarithromycin markedly increases eplerenone exposure, raising the risk of hyperkalemia and associated arrhythmia. Eplerenone labeling contraindicates strong CYP3A4 inhibitors such as clarithromycin.

معنای این تداخل به زبان ساده

Clarithromycin and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clarithromycin belongs to Anti Bacterial; Eplerenone belongs to Cardiovascular.

سطح شواهد: High

چرا رخ می‌دهد

Clarithromycin is a strong CYP3A4 inhibitor and blocks the main metabolic pathway of eplerenone.

اقدام لازم

Do not co-administer; use an antibiotic without strong CYP3A4 inhibition, such as azithromycin, or withhold eplerenone during the course. Check potassium if exposure has occurred.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Eplerenone، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Clarithromycin with Eplerenone?

MediHelp rates the interaction as contraindicated. Clarithromycin and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin markedly increases eplerenone exposure, raising the risk of hyperkalemia and associated arrhythmia. Eplerenone labeling contraindicates strong CYP3A4 inhibitors such as clarithromycin.

How serious is the interaction between Clarithromycin and Eplerenone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an antibiotic without strong CYP3A4 inhibition, such as azithromycin, or withhold eplerenone during the course. Check potassium if exposure has occurred.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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