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تداخل‌های دارویی

Clarithromycin + Valbenazine

شدت: شدید

Clarithromycin and Valbenazine: major interaction.

آخرین به‌روزرسانی

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خلاصه

Clarithromycin raises exposure to valbenazine and its active metabolite via CYP3A4 inhibition, and both drugs can prolong the QT interval. This increases the risk of somnolence and QT-related arrhythmia.

معنای این تداخل به زبان ساده

Clarithromycin and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Valbenazine belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

CYP3A4 inhibition increases valbenazine levels, with additive QT prolongation.

اقدام لازم

Reduce valbenazine to 40 mg daily during clarithromycin therapy, or use a non-interacting antibiotic. Monitor ECG and electrolytes in patients at risk of QT prolongation.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Valbenazine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Clarithromycin with Valbenazine?

MediHelp rates the interaction as major. Clarithromycin and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin raises exposure to valbenazine and its active metabolite via CYP3A4 inhibition, and both drugs can prolong the QT interval. This increases the risk of somnolence and QT-related arrhythmia.

How serious is the interaction between Clarithromycin and Valbenazine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce valbenazine to 40 mg daily during clarithromycin therapy, or use a non-interacting antibiotic. Monitor ECG and electrolytes in patients at risk of QT prolongation.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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