تداخل‌های دارویی
Tranylcypromine + Valbenazine
شدت: منع مصرف
Tranylcypromine and Valbenazine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Valbenazine is a VMAT2 inhibitor that depletes monoamines, and MAOIs raise synaptic monoamine levels. The combination may reduce valbenazine efficacy and may increase the risk of serotonin toxicity. Labeling contraindicates concomitant use with MAOIs.
معنای این تداخل به زبان ساده
Tranylcypromine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tranylcypromine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
چرا رخ می‌دهد
Opposing effects on monoamine disposition: VMAT2 inhibition versus MAO inhibition preventing monoamine breakdown.
اقدام لازم
Do not combine; select an alternative therapy. Observe the washout period recommended in the labeling when changing between agents.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Tranylcypromine و Valbenazine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Tranylcypromine
- 5-HTP + Tranylcypromine منع مصرف
- Amitriptyline + Tranylcypromine منع مصرف
- Amoxapine + Tranylcypromine منع مصرف
- Atomoxetine + Tranylcypromine منع مصرف
- Benzphetamine + Tranylcypromine منع مصرف
- Brimonidine + Tranylcypromine منع مصرف
تداخلات دیگر Valbenazine
پرسش‌های متداول
Can I take Tranylcypromine with Valbenazine?
MediHelp rates the interaction as contraindicated. Tranylcypromine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Valbenazine is a VMAT2 inhibitor that depletes monoamines, and MAOIs raise synaptic monoamine levels. The combination may reduce valbenazine efficacy and may increase the risk of serotonin toxicity. Labeling contraindicates concomitant use with MAOIs.
How serious is the interaction between Tranylcypromine and Valbenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative therapy. Observe the washout period recommended in the labeling when changing between agents.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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