تداخل‌های دارویی
Clotrimazole + Cyclosporine
شدت: متوسط
Clotrimazole and Cyclosporine: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
معنای این تداخل به زبان ساده
Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
چرا رخ می‌دهد
Clotrimazole may inhibit CYP3A4 and P-glycoprotein, reducing cyclosporine clearance.
اقدام لازم
Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clotrimazole و Cyclosporine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Clotrimazole
پرسش‌های متداول
Can I take Clotrimazole with Cyclosporine?
MediHelp rates the interaction as moderate. Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
How serious is the interaction between Clotrimazole and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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