تداخل‌های دارویی
Clotrimazole + Lomitapide
شدت: شدید
Clotrimazole and Lomitapide: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Lomitapide is extensively metabolized by CYP3A4, and strong inhibitors raise its exposure many-fold, increasing the risk of hepatotoxicity and gastrointestinal adverse effects. Systemic clotrimazole is a CYP3A4 inhibitor, though topical or oral lozenge use gives limited exposure.
معنای این تداخل به زبان ساده
Clotrimazole and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clotrimazole belongs to Anti Fungals; Lomitapide belongs to Cardiovascular.
چرا رخ می‌دهد
Clotrimazole inhibits CYP3A4-mediated metabolism of lomitapide, increasing its systemic concentrations.
اقدام لازم
Avoid systemic or prolonged clotrimazole use during lomitapide therapy and choose an antifungal with less CYP3A4 effect. Monitor liver enzymes if exposure cannot be avoided.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clotrimazole و Lomitapide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Clotrimazole
تداخلات دیگر Lomitapide
- Aprepitant + Lomitapide منع مصرف
- Clarithromycin + Lomitapide منع مصرف
- Crizotinib + Lomitapide منع مصرف
- Diltiazem + Lomitapide منع مصرف
- Efavirenz + Lomitapide منع مصرف
- Ensitrelvir + Lomitapide منع مصرف
پرسش‌های متداول
Can I take Clotrimazole with Lomitapide?
MediHelp rates the interaction as major. Clotrimazole and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lomitapide is extensively metabolized by CYP3A4, and strong inhibitors raise its exposure many-fold, increasing the risk of hepatotoxicity and gastrointestinal adverse effects. Systemic clotrimazole is a CYP3A4 inhibitor, though topical or oral lozenge use gives limited exposure.
How serious is the interaction between Clotrimazole and Lomitapide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic or prolonged clotrimazole use during lomitapide therapy and choose an antifungal with less CYP3A4 effect. Monitor liver enzymes if exposure cannot be avoided.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Mavacamten, Mobocertinib, Voclosporin. The full list is on the Clotrimazole page.
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