تداخلهای دارویی
Conivaptan + Red yeast rice
شدت: شدید
Conivaptan and Red yeast rice: major interaction.
آخرین بهروزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Red yeast rice supplies monacolin K, identical to lovastatin, which relies on CYP3A4 for clearance. Conivaptan is a potent CYP3A4 inhibitor, so monacolin K levels may rise and increase the risk of myopathy.
معنای این تداخل به زبان ساده
Conivaptan and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ میدهد
Conivaptan inhibits CYP3A4, decreasing monacolin K metabolism.
اقدام لازم
Avoid the combination and withhold red yeast rice during conivaptan therapy. Monitor for muscle symptoms and creatine kinase if exposure occurs.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Conivaptan و Red yeast rice، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Red yeast rice
- Red yeast rice + Ritonavir منع مصرف
- Red yeast rice + Saquinavir منع مصرف
- Red yeast rice + Tipranavir منع مصرف
- Atazanavir + Red yeast rice شدید
- Atorvastatin + Red yeast rice شدید
- Cyclosporine + Red yeast rice شدید
پرسشهای متداول
Can I take Conivaptan with Red yeast rice?
MediHelp rates the interaction as major. Conivaptan and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice supplies monacolin K, identical to lovastatin, which relies on CYP3A4 for clearance. Conivaptan is a potent CYP3A4 inhibitor, so monacolin K levels may rise and increase the risk of myopathy.
How serious is the interaction between Conivaptan and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and withhold red yeast rice during conivaptan therapy. Monitor for muscle symptoms and creatine kinase if exposure occurs.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
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