تداخل‌های دارویی
Cyclobenzaprine + Linezolid
شدت: منع مصرف
Cyclobenzaprine and Linezolid: contraindicated interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Linezolid is a reversible non-selective MAO inhibitor, and cyclobenzaprine has serotonergic activity, so combined use can precipitate serotonin syndrome. Cyclobenzaprine labeling also contraindicates use with MAO inhibitors because of the risk of severe reactions.
معنای این تداخل به زبان ساده
Cyclobenzaprine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Linezolid belongs to Anti Bacterial.
چرا رخ می‌دهد
MAO inhibition by linezolid combined with serotonin reuptake inhibition by cyclobenzaprine increases synaptic serotonin.
اقدام لازم
Avoid concurrent use and choose an alternative antibiotic or muscle relaxant. If linezolid is essential, stop cyclobenzaprine and monitor for serotonin syndrome.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cyclobenzaprine و Linezolid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid منع مصرف
- Cyclobenzaprine + Phenelzine منع مصرف
- Cyclobenzaprine + Safinamide منع مصرف
- Cyclobenzaprine + Selegiline منع مصرف
- Cyclobenzaprine + Selegiline transdermal منع مصرف
- Cyclobenzaprine + Tranylcypromine منع مصرف
تداخلات دیگر Linezolid
- Amoxapine + Linezolid منع مصرف
- Atomoxetine + Linezolid منع مصرف
- Benzphetamine + Linezolid منع مصرف
- Brimonidine + Linezolid منع مصرف
- Bupropion-naltrexone + Linezolid منع مصرف
- Bupropion + Linezolid منع مصرف
پرسش‌های متداول
Can I take Cyclobenzaprine with Linezolid?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible non-selective MAO inhibitor, and cyclobenzaprine has serotonergic activity, so combined use can precipitate serotonin syndrome. Cyclobenzaprine labeling also contraindicates use with MAO inhibitors because of the risk of severe reactions.
How serious is the interaction between Cyclobenzaprine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative antibiotic or muscle relaxant. If linezolid is essential, stop cyclobenzaprine and monitor for serotonin syndrome.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Phenelzine, Safinamide. The full list is on the Cyclobenzaprine page.
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