تداخل‌های دارویی
Cyclosporin + Revefenacin
شدت: شدید
Cyclosporin and Revefenacin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cyclosporine inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which can raise systemic exposure to the active metabolite of inhaled revefenacin. Higher exposure could increase anticholinergic adverse effects such as dry mouth, urinary retention and tachycardia.
معنای این تداخل به زبان ساده
Cyclosporin and Revefenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Revefenacin belongs to Respiratory.
چرا رخ می‌دهد
Cyclosporine inhibits OATP1B1/OATP1B3-mediated uptake, reducing hepatic clearance of revefenacin's active metabolite.
اقدام لازم
Coadministration is not recommended per labeling; choose an alternative long-acting bronchodilator if cyclosporine is needed. If unavoidable, monitor for anticholinergic effects.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cyclosporin و Revefenacin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin منع مصرف
- Aliskiren + Cyclosporin منع مصرف
- Bcg vaccine live + Cyclosporin منع مصرف
- Bosentan + Cyclosporin منع مصرف
- Cidofovir + Cyclosporin منع مصرف
- Cyclosporin + Dengue vaccine منع مصرف
تداخلات دیگر Revefenacin
پرسش‌های متداول
Can I take Cyclosporin with Revefenacin?
MediHelp rates the interaction as major. Cyclosporin and Revefenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which can raise systemic exposure to the active metabolite of inhaled revefenacin. Higher exposure could increase anticholinergic adverse effects such as dry mouth, urinary retention and tachycardia.
How serious is the interaction between Cyclosporin and Revefenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is not recommended per labeling; choose an alternative long-acting bronchodilator if cyclosporine is needed. If unavoidable, monitor for anticholinergic effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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