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تداخل‌های دارویی

Cyclosporin + Voclosporin

شدت: منع مصرف

Cyclosporin and Voclosporin: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Both are calcineurin inhibitors, so combining them gives duplicate immunosuppression and additive nephrotoxicity, hyperkalemia and infection risk. Cyclosporine also inhibits CYP3A4 and raises voclosporin exposure.

معنای این تداخل به زبان ساده

Cyclosporin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cyclosporin belongs to Miscellaneous; Voclosporin belongs to Miscellaneous.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive calcineurin inhibition with pharmacodynamic overlap, plus cyclosporine-mediated CYP3A4 inhibition that increases voclosporin levels.

اقدام لازم

Do not use the two calcineurin inhibitors together. Use only one agent and allow appropriate washout when switching.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cyclosporin و Voclosporin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Cyclosporin with Voclosporin?

MediHelp rates the interaction as contraindicated. Cyclosporin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are calcineurin inhibitors, so combining them gives duplicate immunosuppression and additive nephrotoxicity, hyperkalemia and infection risk. Cyclosporine also inhibits CYP3A4 and raises voclosporin exposure.

How serious is the interaction between Cyclosporin and Voclosporin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two calcineurin inhibitors together. Use only one agent and allow appropriate washout when switching.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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