Drug interactions
Cyclosporin + Voclosporin
Severity: Contraindicated
Cyclosporin and Voclosporin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are calcineurin inhibitors, so combining them gives duplicate immunosuppression and additive nephrotoxicity, hyperkalemia and infection risk. Cyclosporine also inhibits CYP3A4 and raises voclosporin exposure.
What this interaction means in plain words
Cyclosporin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Voclosporin belongs to Miscellaneous.
Why it happens
Additive calcineurin inhibition with pharmacodynamic overlap, plus cyclosporine-mediated CYP3A4 inhibition that increases voclosporin levels.
What to do
Do not use the two calcineurin inhibitors together. Use only one agent and allow appropriate washout when switching.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
- Voclosporin + Voriconazole Contraindicated
Frequently asked questions
Can I take Cyclosporin with Voclosporin?
MediHelp rates the interaction as contraindicated. Cyclosporin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are calcineurin inhibitors, so combining them gives duplicate immunosuppression and additive nephrotoxicity, hyperkalemia and infection risk. Cyclosporine also inhibits CYP3A4 and raises voclosporin exposure.
How serious is the interaction between Cyclosporin and Voclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two calcineurin inhibitors together. Use only one agent and allow appropriate washout when switching.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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