تداخلهای دارویی
Cyclosporine + Etoposide
شدت: شدید
Cyclosporine and Etoposide: major interaction.
آخرین بهروزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cyclosporine inhibits CYP3A4 and P-glycoprotein and can markedly raise etoposide exposure. This may cause more severe myelosuppression and mucositis, and cyclosporine's own immunosuppression adds to the risk of infection.
معنای این تداخل به زبان ساده
Cyclosporine and Etoposide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ میدهد
Inhibition of P-gp efflux and CYP3A4 metabolism of etoposide by cyclosporine.
اقدام لازم
Reduce the etoposide dose when given with cyclosporine and monitor blood counts closely. Watch for infection and mucositis.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Cyclosporine و Etoposide، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Etoposide
پرسشهای متداول
Can I take Cyclosporine with Etoposide?
MediHelp rates the interaction as major. Cyclosporine and Etoposide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and P-glycoprotein and can markedly raise etoposide exposure. This may cause more severe myelosuppression and mucositis, and cyclosporine's own immunosuppression adds to the risk of infection.
How serious is the interaction between Cyclosporine and Etoposide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the etoposide dose when given with cyclosporine and monitor blood counts closely. Watch for infection and mucositis.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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