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تداخل‌های دارویی

Etoposide + Pentostatin

شدت: منع مصرف

Etoposide and Pentostatin: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

In high-dose transplant conditioning with carmustine and cyclophosphamide, pentostatin was linked to fatal pulmonary edema and hypotension. Use together in this setting is dangerous.

معنای این تداخل به زبان ساده

Etoposide and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Etoposide belongs to Oncology; Pentostatin belongs to Oncology.

سطح شواهد: Moderate

چرا رخ می‌دهد

Mechanism not established; additive pulmonary and cardiovascular toxicity is suspected.

اقدام لازم

Avoid pentostatin with high-dose etoposide-containing ablative regimens and choose a different conditioning approach.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Etoposide و Pentostatin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Etoposide with Pentostatin?

MediHelp rates the interaction as contraindicated. Etoposide and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. In high-dose transplant conditioning with carmustine and cyclophosphamide, pentostatin was linked to fatal pulmonary edema and hypotension. Use together in this setting is dangerous.

How serious is the interaction between Etoposide and Pentostatin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pentostatin with high-dose etoposide-containing ablative regimens and choose a different conditioning approach.

What other medicines interact with Pentostatin?

MediHelp also lists interactions of Pentostatin with, for example, Carmustine, Fludarabine, Cyclophosphamide. The full list is on the Pentostatin page.

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