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تداخل‌های دارویی

Desipramine + Methylene blue

شدت: منع مصرف

Desipramine and Methylene blue: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Methylene blue inhibits MAO-A and, with serotonergic antidepressants such as desipramine, can cause serotonin syndrome. Features include confusion, agitation, myoclonus, hyperthermia and autonomic instability.

معنای این تداخل به زبان ساده

Desipramine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: High

چرا رخ می‌دهد

MAO-A inhibition by methylene blue combined with desipramine reuptake inhibition increases synaptic serotonin.

اقدام لازم

Avoid unless methylene blue is needed for an emergency; if so, stop desipramine and monitor for serotonin toxicity for up to 2 weeks or until 24 hours after the last methylene blue dose.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Desipramine و Methylene blue، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Desipramine with Methylene blue?

MediHelp rates the interaction as contraindicated. Desipramine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits MAO-A and, with serotonergic antidepressants such as desipramine, can cause serotonin syndrome. Features include confusion, agitation, myoclonus, hyperthermia and autonomic instability.

How serious is the interaction between Desipramine and Methylene blue?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless methylene blue is needed for an emergency; if so, stop desipramine and monitor for serotonin toxicity for up to 2 weeks or until 24 hours after the last methylene blue dose.

What other medicines interact with Desipramine?

MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.

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