تداخل‌های دارویی
Desipramine + Phenelzine
شدت: منع مصرف
Desipramine and Phenelzine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Phenelzine inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
معنای این تداخل به زبان ساده
Desipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desipramine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
چرا رخ می‌دهد
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
اقدام لازم
Do not combine; allow at least 14 days after stopping the phenelzine before starting desipramine, and at least 14 days after stopping desipramine before starting the phenelzine.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Desipramine و Phenelzine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Desipramine
- Desipramine + Disopyramide منع مصرف
- Desipramine + Dofetilide منع مصرف
- Desipramine + Ibutilide منع مصرف
- Desipramine + Isocarboxazid منع مصرف
- Desipramine + Methylene blue منع مصرف
- Desipramine + Pentamidine منع مصرف
تداخلات دیگر Phenelzine
- 5-HTP + Phenelzine منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Amoxapine + Phenelzine منع مصرف
- Atomoxetine + Phenelzine منع مصرف
- Benzphetamine + Phenelzine منع مصرف
- Brimonidine + Phenelzine منع مصرف
پرسش‌های متداول
Can I take Desipramine with Phenelzine?
MediHelp rates the interaction as contraindicated. Desipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Desipramine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the phenelzine before starting desipramine, and at least 14 days after stopping desipramine before starting the phenelzine.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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