تداخل‌های دارویی
Dextroamphetamine + Selegiline
شدت: منع مصرف
Dextroamphetamine and Selegiline: contraindicated interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Selegiline inhibits catecholamine breakdown and enlarges neuronal norepinephrine stores, and dextroamphetamine releases norepinephrine and dopamine from nerve terminals. The result can be a hypertensive crisis with severe headache, arrhythmia, hyperpyrexia and intracranial haemorrhage.
معنای این تداخل به زبان ساده
Dextroamphetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dextroamphetamine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
چرا رخ می‌دهد
MAO inhibition plus indirect sympathomimetic norepinephrine release -> exaggerated pressor response
اقدام لازم
Do not give dextroamphetamine during or within 14 days of an MAO inhibitor, and leave at least 14 days after stopping the stimulant before starting the MAO inhibitor.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Dextroamphetamine و Selegiline، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Dextroamphetamine
- Dextroamphetamine + Isocarboxazid منع مصرف
- Dextroamphetamine + Linezolid منع مصرف
- Dextroamphetamine + Methylene blue منع مصرف
- Dextroamphetamine + Phenelzine منع مصرف
- Dextroamphetamine + Rasagiline منع مصرف
- Dextroamphetamine + Safinamide منع مصرف
تداخلات دیگر Selegiline
- Amitriptyline + Selegiline منع مصرف
- Amoxapine + Selegiline منع مصرف
- Atomoxetine + Selegiline منع مصرف
- Benzphetamine + Selegiline منع مصرف
- Brimonidine + Selegiline منع مصرف
- Buprenorphine long-acting + Selegiline منع مصرف
پرسش‌های متداول
Can I take Dextroamphetamine with Selegiline?
MediHelp rates the interaction as contraindicated. Dextroamphetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits catecholamine breakdown and enlarges neuronal norepinephrine stores, and dextroamphetamine releases norepinephrine and dopamine from nerve terminals. The result can be a hypertensive crisis with severe headache, arrhythmia, hyperpyrexia and intracranial haemorrhage.
How serious is the interaction between Dextroamphetamine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give dextroamphetamine during or within 14 days of an MAO inhibitor, and leave at least 14 days after stopping the stimulant before starting the MAO inhibitor.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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