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Dofetilide + Quinine

شدت: منع مصرف

Dofetilide and Quinine: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Both drugs prolong the QT interval, and quinine may also reduce dofetilide renal elimination by competing for cationic tubular secretion. This raises dofetilide levels and the risk of torsades de pointes, a potentially fatal arrhythmia.

معنای این تداخل به زبان ساده

Dofetilide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dofetilide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive QT prolongation combined with competition for renal tubular cationic secretion that increases dofetilide exposure.

اقدام لازم

Avoid concurrent use and choose a non-QT-prolonging antimalarial or alternative antiarrhythmic. If quinine is essential, hold dofetilide and use continuous ECG monitoring.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Dofetilide و Quinine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Dofetilide with Quinine?

MediHelp rates the interaction as contraindicated. Dofetilide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and quinine may also reduce dofetilide renal elimination by competing for cationic tubular secretion. This raises dofetilide levels and the risk of torsades de pointes, a potentially fatal arrhythmia.

How serious is the interaction between Dofetilide and Quinine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging antimalarial or alternative antiarrhythmic. If quinine is essential, hold dofetilide and use continuous ECG monitoring.

What other medicines interact with Quinine?

MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Quinine page.

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