تداخل‌های دارویی
Duloxetine + Linezolid
شدت: منع مصرف
Duloxetine and Linezolid: contraindicated interaction.
آخرین به‌روزرسانی منابع: US FDA label
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Linezolid is a weak reversible nonselective MAO inhibitor, and combining it with duloxetine can cause serotonin syndrome. Features include agitation, confusion, tremor, clonus, hyperreflexia, sweating and fever, and the condition can be life threatening. Duloxetine labeling restricts its use with linezolid except in emergencies where benefits outweigh the risk.
معنای این تداخل به زبان ساده
Duloxetine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duloxetine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
چرا رخ می‌دهد
Linezolid inhibits MAO and reduces serotonin breakdown, while duloxetine blocks serotonin and norepinephrine reuptake, producing excessive serotonergic stimulation.
اقدام لازم
Avoid the combination and choose an alternative antibiotic where possible. If linezolid is urgently required, stop duloxetine and monitor for serotonin toxicity for about 2 weeks or until 24 hours after the last linezolid dose, whichever comes first.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Duloxetine و Linezolid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Duloxetine
- Duloxetine + Isocarboxazid منع مصرف
- Duloxetine + Methylene blue منع مصرف
- Duloxetine + Phenelzine منع مصرف
- Duloxetine + Procarbazine منع مصرف
- Duloxetine + Rasagiline منع مصرف
- Duloxetine + Safinamide منع مصرف
تداخلات دیگر Linezolid
- Amoxapine + Linezolid منع مصرف
- Atomoxetine + Linezolid منع مصرف
- Benzphetamine + Linezolid منع مصرف
- Brimonidine + Linezolid منع مصرف
- Bupropion-naltrexone + Linezolid منع مصرف
- Bupropion + Linezolid منع مصرف
پرسش‌های متداول
Can I take Duloxetine with Linezolid?
MediHelp rates the interaction as contraindicated. Duloxetine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a weak reversible nonselective MAO inhibitor, and combining it with duloxetine can cause serotonin syndrome. Features include agitation, confusion, tremor, clonus, hyperreflexia, sweating and fever, and the condition can be life threatening. Duloxetine labeling restricts its use with linezolid except in emergencies where benefits outweigh the risk.
How serious is the interaction between Duloxetine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antibiotic where possible. If linezolid is urgently required, stop duloxetine and monitor for serotonin toxicity for about 2 weeks or until 24 hours after the last linezolid dose, whichever comes first.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Duloxetine page.
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