تداخل‌های دارویی
Etrasimod + Topotecan
شدت: شدید
Etrasimod and Topotecan: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Etrasimod lowers circulating lymphocytes, and topotecan is myelosuppressive, so combined use may increase the risk of infection. Combined effects have not been formally studied.
معنای این تداخل به زبان ساده
Etrasimod and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Topotecan belongs to Oncology.
چرا رخ می‌دهد
Additive immunosuppression from S1P receptor modulation (lymphocyte sequestration) and cytotoxic bone marrow suppression.
اقدام لازم
Avoid starting etrasimod during chemotherapy and for some weeks afterward if possible. If combined, monitor blood counts and infection signs closely.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Etrasimod و Topotecan، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Topotecan
تداخلات دیگر Etrasimod
پرسش‌های متداول
Can I take Etrasimod with Topotecan?
MediHelp rates the interaction as major. Etrasimod and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes, and topotecan is myelosuppressive, so combined use may increase the risk of infection. Combined effects have not been formally studied.
How serious is the interaction between Etrasimod and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting etrasimod during chemotherapy and for some weeks afterward if possible. If combined, monitor blood counts and infection signs closely.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
