Famciclovir + Tenofovir disoproxil

MediHelp rates the interaction as minor. Famciclovir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of famciclovir, penciclovir, is renally eliminated, and competition for tubular secretion with tenofovir could modestly raise either drug's level. A significant clinical effect is not well documented.

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and adjust famciclovir dose when creatinine clearance is reduced.

MediHelp also lists interactions of Famciclovir with, for example, Talimogene laherparepvec, Varicella virus vaccine live, Zoster vaccine live. The full list is on the Famciclovir page.