Drug interactions
Famciclovir + Tenofovir disoproxil
Severity: Minor
Famciclovir and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of famciclovir, penciclovir, is renally eliminated, and competition for tubular secretion with tenofovir could modestly raise either drug's level. A significant clinical effect is not well documented.
What this interaction means in plain words
Famciclovir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for active renal tubular secretion.
What to do
No routine adjustment is needed. Monitor renal function and adjust famciclovir dose when creatinine clearance is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Famciclovir
Frequently asked questions
Can I take Famciclovir with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Famciclovir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of famciclovir, penciclovir, is renally eliminated, and competition for tubular secretion with tenofovir could modestly raise either drug's level. A significant clinical effect is not well documented.
How serious is the interaction between Famciclovir and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and adjust famciclovir dose when creatinine clearance is reduced.
What other medicines interact with Famciclovir?
MediHelp also lists interactions of Famciclovir with, for example, Talimogene laherparepvec, Varicella virus vaccine live, Zoster vaccine live. The full list is on the Famciclovir page.
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