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تداخل‌های دارویی

Fingolimod + Ponesimod

شدت: منع مصرف

Fingolimod and Ponesimod: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Both are sphingosine-1-phosphate receptor modulators that lower heart rate and reduce circulating lymphocytes. Using them together duplicates therapy and increases the risk of bradyarrhythmia, conduction delay and infection.

معنای این تداخل به زبان ساده

Fingolimod and Ponesimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fingolimod belongs to Central Nervous System; Ponesimod belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

Duplicate S1P receptor modulation producing additive negative chronotropic and immunosuppressive effects.

اقدام لازم

Do not combine; allow adequate washout of one agent, guided by labeling, before starting the other, with cardiac monitoring at initiation.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fingolimod و Ponesimod، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Fingolimod with Ponesimod?

MediHelp rates the interaction as contraindicated. Fingolimod and Ponesimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are sphingosine-1-phosphate receptor modulators that lower heart rate and reduce circulating lymphocytes. Using them together duplicates therapy and increases the risk of bradyarrhythmia, conduction delay and infection.

How serious is the interaction between Fingolimod and Ponesimod?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow adequate washout of one agent, guided by labeling, before starting the other, with cardiac monitoring at initiation.

What other medicines interact with Fingolimod?

MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.

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