تداخل‌های دارویی
Fludrocortisone + Glycerol phenylbutyrate
شدت: متوسط
Fludrocortisone and Glycerol phenylbutyrate: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Corticosteroids promote protein breakdown and can raise plasma ammonia, which counteracts the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders. This may risk hyperammonemia.
معنای این تداخل به زبان ساده
Fludrocortisone and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Glycerol phenylbutyrate belongs to Miscellaneous.
چرا رخ می‌دهد
Corticosteroid-driven protein catabolism increases nitrogen load and ammonia production, opposing the nitrogen scavenging effect.
اقدام لازم
Monitor plasma ammonia closely when fludrocortisone is started or adjusted, and adjust the glycerol phenylbutyrate dose or protein intake as needed.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fludrocortisone و Glycerol phenylbutyrate، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Fludrocortisone
تداخلات دیگر Glycerol phenylbutyrate
پرسش‌های متداول
Can I take Fludrocortisone with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Fludrocortisone and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein breakdown and can raise plasma ammonia, which counteracts the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders. This may risk hyperammonemia.
How serious is the interaction between Fludrocortisone and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when fludrocortisone is started or adjusted, and adjust the glycerol phenylbutyrate dose or protein intake as needed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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