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تداخل‌های دارویی

Fluvastatin + Letermovir

شدت: شدید

Fluvastatin and Letermovir: major interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Letermovir inhibits OATP1B1/3 and raises exposure of many statins, and fluvastatin concentrations may also increase. This raises the risk of myopathy and rhabdomyolysis, and use is not recommended when cyclosporine is also given.

معنای این تداخل به زبان ساده

Fluvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fluvastatin belongs to Cardiovascular; Letermovir belongs to Anti Virals.

سطح شواهد: Moderate

چرا رخ می‌دهد

Letermovir inhibits OATP1B1/3 hepatic uptake and possibly BCRP, increasing fluvastatin exposure.

اقدام لازم

Consider reducing the fluvastatin dose and monitor closely for muscle symptoms. Avoid fluvastatin if the patient also receives cyclosporine.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fluvastatin و Letermovir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Fluvastatin with Letermovir?

MediHelp rates the interaction as major. Fluvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir inhibits OATP1B1/3 and raises exposure of many statins, and fluvastatin concentrations may also increase. This raises the risk of myopathy and rhabdomyolysis, and use is not recommended when cyclosporine is also given.

How serious is the interaction between Fluvastatin and Letermovir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the fluvastatin dose and monitor closely for muscle symptoms. Avoid fluvastatin if the patient also receives cyclosporine.

What other medicines interact with Fluvastatin?

MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.

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