تداخل‌های دارویی
Folic acid + Glucarpidase
شدت: متوسط
Folic acid and Glucarpidase: moderate interaction.
آخرین به‌روزرسانی
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خلاصه
Glucarpidase hydrolyzes folates and antifolates such as methotrexate, and can degrade folic acid and related folate compounds like leucovorin. Folate rescue given around glucarpidase may therefore be less effective.
معنای این تداخل به زبان ساده
Folic acid and Glucarpidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Glucarpidase belongs to Miscellaneous.
چرا رخ می‌دهد
Glucarpidase is a carboxypeptidase that cleaves the terminal glutamate residue from folates, inactivating them.
اقدام لازم
Do not give leucovorin within 2 hours before or after glucarpidase, since it is a substrate, and continue folate rescue as directed by the protocol afterward.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Folic acid و Glucarpidase، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Folic acid
تداخلات دیگر Glucarpidase
پرسش‌های متداول
Can I take Folic acid with Glucarpidase?
MediHelp rates the interaction as moderate. Folic acid and Glucarpidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucarpidase hydrolyzes folates and antifolates such as methotrexate, and can degrade folic acid and related folate compounds like leucovorin. Folate rescue given around glucarpidase may therefore be less effective.
How serious is the interaction between Folic acid and Glucarpidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give leucovorin within 2 hours before or after glucarpidase, since it is a substrate, and continue folate rescue as directed by the protocol afterward.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Fosphenytoin, Methotrexate. The full list is on the Folic acid page.
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