تداخل‌های دارویی
Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir
شدت: منع مصرف
Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Gemfibrozil strongly inhibits CYP2C8, which is the main route of dasabuvir clearance. Dasabuvir concentrations rise several-fold, raising concern for QT prolongation. The combination is contraindicated in labeling.
معنای این تداخل به زبان ساده
Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
Gemfibrozil and its glucuronide inhibit CYP2C8-mediated metabolism of dasabuvir, markedly increasing its plasma levels.
اقدام لازم
Do not use together. Switch to a different lipid-lowering drug, such as fenofibrate or a statin, before starting the antiviral regimen.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Gemfibrozil و Ombitasvir / paritaprevir / ritonavir and dasabuvir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Gemfibrozil
- Daprodustat + Gemfibrozil منع مصرف
- Elagolix + Gemfibrozil منع مصرف
- Gemfibrozil + Mavacamten منع مصرف
- Gemfibrozil + Metformin-repaglinide منع مصرف
- Gemfibrozil + Repaglinide منع مصرف
- Gemfibrozil + Selexipag منع مصرف
پرسش‌های متداول
Can I take Gemfibrozil with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil strongly inhibits CYP2C8, which is the main route of dasabuvir clearance. Dasabuvir concentrations rise several-fold, raising concern for QT prolongation. The combination is contraindicated in labeling.
How serious is the interaction between Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Switch to a different lipid-lowering drug, such as fenofibrate or a statin, before starting the antiviral regimen.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
