Drug interactions
Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Contraindicated
Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil strongly inhibits CYP2C8, which is the main route of dasabuvir clearance. Dasabuvir concentrations rise several-fold, raising concern for QT prolongation. The combination is contraindicated in labeling.
What this interaction means in plain words
Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Gemfibrozil and its glucuronide inhibit CYP2C8-mediated metabolism of dasabuvir, markedly increasing its plasma levels.
What to do
Do not use together. Switch to a different lipid-lowering drug, such as fenofibrate or a statin, before starting the antiviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
- Gemfibrozil + Selexipag Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil strongly inhibits CYP2C8, which is the main route of dasabuvir clearance. Dasabuvir concentrations rise several-fold, raising concern for QT prolongation. The combination is contraindicated in labeling.
How serious is the interaction between Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Switch to a different lipid-lowering drug, such as fenofibrate or a statin, before starting the antiviral regimen.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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