تداخل‌های دارویی
Human parathyroid hormone recombinant + Zoledronic acid
شدت: متوسط
Human parathyroid hormone recombinant and Zoledronic acid: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Zoledronic acid is a potent inhibitor of bone resorption and may reduce the calcium-mobilising effect of recombinant PTH. This could make it harder to normalise serum calcium in patients treated for hypoparathyroidism.
معنای این تداخل به زبان ساده
Human parathyroid hormone recombinant and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
چرا رخ می‌دهد
Pharmacodynamic opposition: bisphosphonates suppress osteoclast-mediated bone resorption that PTH stimulates.
اقدام لازم
Monitor serum calcium closely and adjust calcium and vitamin D or PTH doses as needed. Avoid concurrent use unless clearly indicated.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Human parathyroid hormone recombinant و Zoledronic acid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Zoledronic acid
پرسش‌های متداول
Can I take Human parathyroid hormone recombinant with Zoledronic acid?
MediHelp rates the interaction as moderate. Human parathyroid hormone recombinant and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zoledronic acid is a potent inhibitor of bone resorption and may reduce the calcium-mobilising effect of recombinant PTH. This could make it harder to normalise serum calcium in patients treated for hypoparathyroidism.
How serious is the interaction between Human parathyroid hormone recombinant and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium closely and adjust calcium and vitamin D or PTH doses as needed. Avoid concurrent use unless clearly indicated.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
