Drug interactions
Human parathyroid hormone recombinant + Zoledronic acid
Severity: Moderate
Human parathyroid hormone recombinant and Zoledronic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zoledronic acid is a potent inhibitor of bone resorption and may reduce the calcium-mobilising effect of recombinant PTH. This could make it harder to normalise serum calcium in patients treated for hypoparathyroidism.
What this interaction means in plain words
Human parathyroid hormone recombinant and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition: bisphosphonates suppress osteoclast-mediated bone resorption that PTH stimulates.
What to do
Monitor serum calcium closely and adjust calcium and vitamin D or PTH doses as needed. Avoid concurrent use unless clearly indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zoledronic acid
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
Frequently asked questions
Can I take Human parathyroid hormone recombinant with Zoledronic acid?
MediHelp rates the interaction as moderate. Human parathyroid hormone recombinant and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zoledronic acid is a potent inhibitor of bone resorption and may reduce the calcium-mobilising effect of recombinant PTH. This could make it harder to normalise serum calcium in patients treated for hypoparathyroidism.
How serious is the interaction between Human parathyroid hormone recombinant and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium closely and adjust calcium and vitamin D or PTH doses as needed. Avoid concurrent use unless clearly indicated.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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