تداخل‌های دارویی
Insulin degludec + Pioglitazone
شدت: شدید
Insulin degludec and Pioglitazone: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Pioglitazone increases insulin sensitivity and enhances the glucose-lowering effect of insulin, which increases hypoglycemia risk. Both drugs can also cause fluid retention, so the combination raises the risk of edema and heart failure.
معنای این تداخل به زبان ساده
Insulin degludec and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Pioglitazone belongs to Endocrine.
چرا رخ می‌دهد
Additive glucose lowering from improved insulin sensitivity plus exogenous insulin; thiazolidinedione-related fluid retention is also additive with insulin.
اقدام لازم
Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Monitor for weight gain, edema and heart failure symptoms, and avoid in patients with symptomatic heart failure.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Insulin degludec و Pioglitazone، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Insulin degludec
تداخلات دیگر Pioglitazone
پرسش‌های متداول
Can I take Insulin degludec with Pioglitazone?
MediHelp rates the interaction as major. Insulin degludec and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pioglitazone increases insulin sensitivity and enhances the glucose-lowering effect of insulin, which increases hypoglycemia risk. Both drugs can also cause fluid retention, so the combination raises the risk of edema and heart failure.
How serious is the interaction between Insulin degludec and Pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Monitor for weight gain, edema and heart failure symptoms, and avoid in patients with symptomatic heart failure.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
