تداخل‌های دارویی
Isavuconazole + Sirolimus
شدت: شدید
Isavuconazole and Sirolimus: major interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Isavuconazole, a moderate CYP3A4 inhibitor, can increase sirolimus concentrations, leading to toxicity such as hyperlipidemia, cytopenias, impaired wound healing, and infections. The size of the effect is smaller than with voriconazole or posaconazole but still clinically important and variable between patients. The isavuconazonium label recommends monitoring sirolimus concentrations.
معنای این تداخل به زبان ساده
Isavuconazole and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isavuconazole belongs to Anti Fungals; Sirolimus belongs to Miscellaneous.
چرا رخ می‌دهد
Isavuconazole inhibits CYP3A4 (and P-glycoprotein), reducing the metabolism and efflux of sirolimus.
اقدام لازم
Measure sirolimus trough before starting isavuconazole, then frequently during co-therapy, and reduce the sirolimus dose as guided by levels. Reassess levels after isavuconazole is stopped, since sirolimus may need to be increased again.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Isavuconazole و Sirolimus، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Isavuconazole
- Carbamazepine + Isavuconazole منع مصرف
- Efavirenz + Isavuconazole منع مصرف
- Etravirine + Isavuconazole منع مصرف
- Isavuconazole + Ketoconazole منع مصرف
- Isavuconazole + Phenobarbitone منع مصرف
- Isavuconazole + Phenytoin منع مصرف
تداخلات دیگر Sirolimus
پرسش‌های متداول
Can I take Isavuconazole with Sirolimus?
MediHelp rates the interaction as major. Isavuconazole and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isavuconazole, a moderate CYP3A4 inhibitor, can increase sirolimus concentrations, leading to toxicity such as hyperlipidemia, cytopenias, impaired wound healing, and infections. The size of the effect is smaller than with voriconazole or posaconazole but still clinically important and variable between patients. The isavuconazonium label recommends monitoring sirolimus concentrations.
How serious is the interaction between Isavuconazole and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure sirolimus trough before starting isavuconazole, then frequently during co-therapy, and reduce the sirolimus dose as guided by levels. Reassess levels after isavuconazole is stopped, since sirolimus may need to be increased again.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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