Drug interactions
isavuconazole + sirolimus
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked ↑ sirolimus levels → toxicity.
Mechanism of action
Strong CYP3A4 inhibition.
Clinical management
Avoid or drastically reduce sirolimus with therapeutic drug monitoring.
Drug reference
References
- Sirolimus – Label interactions — FDA Label
- Azoles with mTOR inhibitors — PubMed
Frequently asked questions
Can I take isavuconazole with sirolimus?
The interaction is rated: Major. Marked ↑ sirolimus levels → toxicity.
How serious is the interaction between isavuconazole and sirolimus?
The interaction is rated: Major. Evidence level: High.
How is the interaction between isavuconazole and sirolimus managed?
Avoid or drastically reduce sirolimus with therapeutic drug monitoring.
Why do isavuconazole and sirolimus interact?
Strong CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.