تداخل‌های دارویی
Isosorbide mononitrate + Tadalafil
شدت: منع مصرف
Isosorbide mononitrate and Tadalafil: contraindicated interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Tadalafil markedly potentiates the hypotensive effect of nitrates, which can cause severe, potentially life-threatening hypotension, syncope or myocardial ischaemia. The effect persists for a prolonged period because of tadalafil's long half-life. Nitrates in any form are contraindicated with tadalafil.
معنای این تداخل به زبان ساده
Isosorbide mononitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide mononitrate belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
چرا رخ می‌دهد
Nitrates increase cGMP by nitric oxide release while tadalafil inhibits PDE5-mediated cGMP breakdown, causing excessive vasodilation.
اقدام لازم
Do not coadminister. Nitrates should not be given within at least 48 hours after tadalafil, and in emergencies the decision should be under close medical supervision.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Isosorbide mononitrate و Tadalafil، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
- Cialis (tadalafil) Prescribing Information - Contraindications — FDA Label
- Cialis SmPC - Contraindications — EMA SmPC
تداخلات دیگر Tadalafil
- Amyl nitrite + Tadalafil منع مصرف
- Isosorbide dinitrate + Tadalafil منع مصرف
- Nitroglycerin po + Tadalafil منع مصرف
- Nitroglycerin rectal + Tadalafil منع مصرف
- Nitroglycerin sublingual + Tadalafil منع مصرف
- Nitroglycerin transdermal + Tadalafil منع مصرف
تداخلات دیگر Isosorbide mononitrate
پرسش‌های متداول
Can I take Isosorbide mononitrate with Tadalafil?
MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil markedly potentiates the hypotensive effect of nitrates, which can cause severe, potentially life-threatening hypotension, syncope or myocardial ischaemia. The effect persists for a prolonged period because of tadalafil's long half-life. Nitrates in any form are contraindicated with tadalafil.
How serious is the interaction between Isosorbide mononitrate and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Nitrates should not be given within at least 48 hours after tadalafil, and in emergencies the decision should be under close medical supervision.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Nitroglycerin po. The full list is on the Tadalafil page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
