تداخلهای دارویی
Ergotamine + Isosorbide mononitrate
شدت: شدید
Ergotamine and Isosorbide mononitrate: major interaction.
آخرین بهروزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصهای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمیشود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Ergotamine causes vasoconstriction and can provoke angina or raise blood pressure, opposing the antianginal action of nitrates. Ergot derivatives may also reduce the effect of nitrates, and the clinical effect is a loss of antianginal efficacy.
معنای این تداخل به زبان ساده
Ergotamine and Isosorbide mononitrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Isosorbide mononitrate belongs to Cardiovascular.
چرا رخ میدهد
Pharmacodynamic antagonism between ergotamine vasoconstriction and nitrate vasodilation.
اقدام لازم
Avoid in patients with coronary disease; choose a non-ergot migraine therapy that is safe in ischaemic heart disease where possible, and monitor for angina and blood pressure rise if unavoidable.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Ergotamine و Isosorbide mononitrate، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Isosorbide mononitrate
تداخلات دیگر Ergotamine
- Almotriptan + Ergotamine منع مصرف
- Atazanavir + Ergotamine منع مصرف
- Clarithromycin + Ergotamine منع مصرف
- Cobicistat + Ergotamine منع مصرف
- Darunavir + Ergotamine منع مصرف
- Dihydroergotamine intranasal + Ergotamine منع مصرف
پرسشهای متداول
Can I take Ergotamine with Isosorbide mononitrate?
MediHelp rates the interaction as major. Ergotamine and Isosorbide mononitrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergotamine causes vasoconstriction and can provoke angina or raise blood pressure, opposing the antianginal action of nitrates. Ergot derivatives may also reduce the effect of nitrates, and the clinical effect is a loss of antianginal efficacy.
How serious is the interaction between Ergotamine and Isosorbide mononitrate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with coronary disease; choose a non-ergot migraine therapy that is safe in ischaemic heart disease where possible, and monitor for angina and blood pressure rise if unavoidable.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
تکنگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.