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تداخل‌های دارویی

Ketorolac + Warfarin

شدت: منع مصرف

Ketorolac and Warfarin: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Ketorolac inhibits platelet function and can cause gastrointestinal ulceration, so combined with warfarin it markedly increases the risk of serious bleeding. Ketorolac is contraindicated in patients at high bleeding risk and with anticoagulants per labeling.

معنای این تداخل به زبان ساده

Ketorolac and Warfarin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ketorolac belongs to Musculoskeletal; Warfarin belongs to Cardiovascular.

سطح شواهد: High

چرا رخ می‌دهد

Additive impairment of hemostasis: ketorolac inhibits platelet aggregation and damages gastric mucosa while warfarin reduces clotting factor synthesis.

اقدام لازم

Avoid ketorolac in patients on warfarin and use a non-NSAID analgesic such as paracetamol. If an NSAID is unavoidable, monitor INR and watch for bleeding with gastroprotection.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Ketorolac و Warfarin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Ketorolac with Warfarin?

MediHelp rates the interaction as contraindicated. Ketorolac and Warfarin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and can cause gastrointestinal ulceration, so combined with warfarin it markedly increases the risk of serious bleeding. Ketorolac is contraindicated in patients at high bleeding risk and with anticoagulants per labeling.

How serious is the interaction between Ketorolac and Warfarin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients on warfarin and use a non-NSAID analgesic such as paracetamol. If an NSAID is unavoidable, monitor INR and watch for bleeding with gastroprotection.

What other medicines interact with Ketorolac?

MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.

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