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تداخل‌های دارویی

Levofloxacin + Thioridazine

شدت: منع مصرف

Levofloxacin and Thioridazine: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Thioridazine is strongly associated with dose-related QT prolongation and torsades de pointes, and its labeling contraindicates use with other QT-prolonging drugs. Adding levofloxacin compounds the arrhythmia risk.

معنای این تداخل به زبان ساده

Levofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Levofloxacin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.

سطح شواهد: High

چرا رخ می‌دهد

Additive blockade of cardiac potassium channels causing marked delay in ventricular repolarization.

اقدام لازم

Do not co-administer; select an antibiotic without QT liability. If a fluoroquinolone is unavoidable, thioridazine should be held under specialist guidance.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Levofloxacin و Thioridazine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Levofloxacin with Thioridazine?

MediHelp rates the interaction as contraindicated. Levofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is strongly associated with dose-related QT prolongation and torsades de pointes, and its labeling contraindicates use with other QT-prolonging drugs. Adding levofloxacin compounds the arrhythmia risk.

How serious is the interaction between Levofloxacin and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an antibiotic without QT liability. If a fluoroquinolone is unavoidable, thioridazine should be held under specialist guidance.

What other medicines interact with Levofloxacin?

MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Vandetanib. The full list is on the Levofloxacin page.

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