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Lidocaine + Pefloxacin

شدت: متوسط

Lidocaine and Pefloxacin: moderate interaction.

آخرین به‌روزرسانی

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خلاصه

Fluoroquinolones that inhibit CYP1A2 can reduce lidocaine clearance and raise its concentrations. Pefloxacin is a CYP1A2 inhibitor and this may lead to lidocaine toxicity with systemic or repeated dosing.

معنای این تداخل به زبان ساده

Lidocaine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Lidocaine belongs to Cardiovascular; Pefloxacin belongs to Anti Bacterial.

سطح شواهد: Low

چرا رخ می‌دهد

Inhibition of CYP1A2-mediated lidocaine metabolism reduces clearance.

اقدام لازم

With systemic lidocaine infusion, monitor for signs of toxicity and consider dose reduction; no change is usually needed for single local anesthetic doses.

از داروساز چه بپرسید

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Lidocaine و Pefloxacin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Lidocaine with Pefloxacin?

MediHelp rates the interaction as moderate. Lidocaine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones that inhibit CYP1A2 can reduce lidocaine clearance and raise its concentrations. Pefloxacin is a CYP1A2 inhibitor and this may lead to lidocaine toxicity with systemic or repeated dosing.

How serious is the interaction between Lidocaine and Pefloxacin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic lidocaine infusion, monitor for signs of toxicity and consider dose reduction; no change is usually needed for single local anesthetic doses.

What other medicines interact with Lidocaine?

MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.

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