تداخل‌های دارویی
Lidocaine + Procainamide
شدت: شدید
Lidocaine and Procainamide: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both are class I antiarrhythmics that depress cardiac conduction, so combined use can cause additive effects such as conduction delay, hypotension and proarrhythmia. Additive CNS toxicity, such as confusion or seizures, has also been described with both agents.
معنای این تداخل به زبان ساده
Lidocaine and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Additive sodium channel blockade slowing cardiac conduction, with overlapping CNS toxicity.
اقدام لازم
Use together only with continuous ECG and blood pressure monitoring, and avoid unless clearly necessary. Reduce doses and watch for QRS widening, hypotension and neurologic symptoms.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Lidocaine و Procainamide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Lidocaine
پرسش‌های متداول
Can I take Lidocaine with Procainamide?
MediHelp rates the interaction as major. Lidocaine and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are class I antiarrhythmics that depress cardiac conduction, so combined use can cause additive effects such as conduction delay, hypotension and proarrhythmia. Additive CNS toxicity, such as confusion or seizures, has also been described with both agents.
How serious is the interaction between Lidocaine and Procainamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only with continuous ECG and blood pressure monitoring, and avoid unless clearly necessary. Reduce doses and watch for QRS widening, hypotension and neurologic symptoms.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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