تداخل‌های دارویی
Lithium + Thioridazine
شدت: منع مصرف
Lithium and Thioridazine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Thioridazine strongly prolongs the QTc interval and can cause torsades de pointes, and lithium can add to QT effects and electrolyte disturbance. Combined use may also raise the risk of neurotoxicity. Thioridazine labeling carries a boxed warning on QT risk and the pair is generally avoided.
معنای این تداخل به زبان ساده
Lithium and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lithium belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
چرا رخ می‌دهد
Additive QT prolongation, with possible pharmacodynamic neurotoxic synergy.
اقدام لازم
Avoid the combination and use a lower-QT-risk antipsychotic. If lithium must be continued, obtain an ECG, check potassium and magnesium, and monitor for neurotoxicity.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Lithium و Thioridazine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Lithium
تداخلات دیگر Thioridazine
- Abiraterone + Thioridazine منع مصرف
- Adagrasib + Thioridazine منع مصرف
- Amiodarone + Thioridazine منع مصرف
- Amisulpride + Thioridazine منع مصرف
- Amitriptyline + Thioridazine منع مصرف
- Amoxapine + Thioridazine منع مصرف
پرسش‌های متداول
Can I take Lithium with Thioridazine?
MediHelp rates the interaction as contraindicated. Lithium and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine strongly prolongs the QTc interval and can cause torsades de pointes, and lithium can add to QT effects and electrolyte disturbance. Combined use may also raise the risk of neurotoxicity. Thioridazine labeling carries a boxed warning on QT risk and the pair is generally avoided.
How serious is the interaction between Lithium and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a lower-QT-risk antipsychotic. If lithium must be continued, obtain an ECG, check potassium and magnesium, and monitor for neurotoxicity.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Vandetanib, Aceclofenac, Acemetacin. The full list is on the Lithium page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
