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تداخل‌های دارویی

Measles mumps and rubella vaccine live + Methotrexate

شدت: منع مصرف

Measles mumps and rubella vaccine live and Methotrexate: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Live MMR vaccine may cause disseminated vaccine-virus infection in patients receiving methotrexate, and the immune response may be impaired. Low-dose methotrexate is sometimes judged acceptable in individual cases, but higher doses clearly raise risk.

معنای این تداخل به زبان ساده

Measles mumps and rubella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: Moderate

چرا رخ می‌دهد

Methotrexate suppresses lymphocyte proliferation, allowing replication of live attenuated viruses.

اقدام لازم

Avoid live MMR during methotrexate therapy; vaccinate at least 4 weeks before starting if possible. Any decision to vaccinate on low-dose methotrexate should be specialist-led.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Measles mumps and rubella vaccine live و Methotrexate، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Measles mumps and rubella vaccine live with Methotrexate?

MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live MMR vaccine may cause disseminated vaccine-virus infection in patients receiving methotrexate, and the immune response may be impaired. Low-dose methotrexate is sometimes judged acceptable in individual cases, but higher doses clearly raise risk.

How serious is the interaction between Measles mumps and rubella vaccine live and Methotrexate?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live MMR during methotrexate therapy; vaccinate at least 4 weeks before starting if possible. Any decision to vaccinate on low-dose methotrexate should be specialist-led.

What other medicines interact with Methotrexate?

MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.

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