تداخل‌های دارویی
Measles mumps and rubella vaccine + Methotrexate
شدت: منع مصرف
Measles mumps and rubella vaccine and Methotrexate: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Methotrexate suppresses cellular and humoral immunity, so a live attenuated vaccine may produce a weaker antibody response. The vaccine viruses may also replicate unchecked, which raises the risk of disseminated vaccine-strain infection. Low-dose methotrexate carries less risk than high-dose regimens, but live vaccines remain generally avoided.
معنای این تداخل به زبان ساده
Measles mumps and rubella vaccine and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Methotrexate belongs to Oncology.
چرا رخ می‌دهد
Antimetabolite-induced immunosuppression impairs the immune response to live attenuated virus and permits vaccine virus replication.
اقدام لازم
Give live vaccines at least 4 weeks before starting methotrexate where possible, and avoid them during treatment. After stopping, wait about 3 months or until immune recovery is confirmed; specialist review is needed for low-dose cases.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Measles mumps and rubella vaccine و Methotrexate، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine منع مصرف
- Anakinra + Measles mumps and rubella vaccine منع مصرف
- Antithymocyte globulin equine + Measles mumps and rubella vaccine منع مصرف
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine منع مصرف
- Azathioprine + Measles mumps and rubella vaccine منع مصرف
- Basiliximab + Measles mumps and rubella vaccine منع مصرف
تداخلات دیگر Methotrexate
- Acitretin + Methotrexate منع مصرف
- Adenovirus types 4 and 7 live + Methotrexate منع مصرف
- Influenza virus vaccine quadrivalent intranasal + Methotrexate منع مصرف
- Ketorolac + Methotrexate منع مصرف
- Measles mumps and rubella vaccine live + Methotrexate منع مصرف
- Measles mumps rubella and varicella vaccine live + Methotrexate منع مصرف
پرسش‌های متداول
Can I take Measles mumps and rubella vaccine with Methotrexate?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methotrexate suppresses cellular and humoral immunity, so a live attenuated vaccine may produce a weaker antibody response. The vaccine viruses may also replicate unchecked, which raises the risk of disseminated vaccine-strain infection. Low-dose methotrexate carries less risk than high-dose regimens, but live vaccines remain generally avoided.
How serious is the interaction between Measles mumps and rubella vaccine and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live vaccines at least 4 weeks before starting methotrexate where possible, and avoid them during treatment. After stopping, wait about 3 months or until immune recovery is confirmed; specialist review is needed for low-dose cases.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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