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تداخل‌های دارویی

Meperidine + Methylene blue

شدت: منع مصرف

Meperidine and Methylene blue: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Methylene blue inhibits MAO-A and, with serotonergic meperidine, can precipitate serotonin syndrome. Severe reactions with confusion, hyperthermia and seizures have been described.

معنای این تداخل به زبان ساده

Meperidine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: High

چرا رخ می‌دهد

MAO-A inhibition by methylene blue combined with serotonin reuptake inhibition by meperidine increases synaptic serotonin.

اقدام لازم

Avoid; if methylene blue is urgently required, stop meperidine and monitor for CNS toxicity, delaying resumption for 24 hours after the last methylene blue dose, or until 2 weeks have passed if monitoring continues.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Meperidine و Methylene blue، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Meperidine with Methylene blue?

MediHelp rates the interaction as contraindicated. Meperidine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits MAO-A and, with serotonergic meperidine, can precipitate serotonin syndrome. Severe reactions with confusion, hyperthermia and seizures have been described.

How serious is the interaction between Meperidine and Methylene blue?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; if methylene blue is urgently required, stop meperidine and monitor for CNS toxicity, delaying resumption for 24 hours after the last methylene blue dose, or until 2 weeks have passed if monitoring continues.

What other medicines interact with Meperidine?

MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Meperidine page.

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