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تداخل‌های دارویی

Meperidine + Procarbazine

شدت: منع مصرف

Meperidine and Procarbazine: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Procarbazine has MAO-inhibiting properties, and meperidine with MAO inhibitors can cause severe, sometimes fatal serotonin syndrome or excitatory reactions with hyperthermia. Meperidine is the opioid most associated with this reaction.

معنای این تداخل به زبان ساده

Meperidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Meperidine belongs to Musculoskeletal; Procarbazine belongs to Oncology.

سطح شواهد: Moderate

چرا رخ می‌دهد

MAO inhibition combined with meperidine's serotonin reuptake inhibition leading to serotonin excess.

اقدام لازم

Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-serotonergic analgesic such as morphine, with monitoring.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Meperidine و Procarbazine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Meperidine with Procarbazine?

MediHelp rates the interaction as contraindicated. Meperidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting properties, and meperidine with MAO inhibitors can cause severe, sometimes fatal serotonin syndrome or excitatory reactions with hyperthermia. Meperidine is the opioid most associated with this reaction.

How serious is the interaction between Meperidine and Procarbazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-serotonergic analgesic such as morphine, with monitoring.

What other medicines interact with Meperidine?

MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.

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