تداخل‌های دارویی
Methyldopa + Pretomanid
شدت: شدید
Methyldopa and Pretomanid: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Pretomanid-containing regimens are associated with hepatotoxicity, and methyldopa can also cause liver injury. Concurrent use may increase the risk of clinically significant hepatic damage.
معنای این تداخل به زبان ساده
Methyldopa and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methyldopa belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
چرا رخ می‌دهد
Additive hepatotoxicity from two drugs that can independently injure the liver.
اقدام لازم
Avoid methyldopa during pretomanid therapy and use an alternative antihypertensive. If unavoidable, monitor liver function tests frequently.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Methyldopa و Pretomanid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Methyldopa
تداخلات دیگر Pretomanid
پرسش‌های متداول
Can I take Methyldopa with Pretomanid?
MediHelp rates the interaction as major. Methyldopa and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and methyldopa can also cause liver injury. Concurrent use may increase the risk of clinically significant hepatic damage.
How serious is the interaction between Methyldopa and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid methyldopa during pretomanid therapy and use an alternative antihypertensive. If unavoidable, monitor liver function tests frequently.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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