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تداخل‌های دارویی

Morphine + Tranylcypromine

شدت: منع مصرف

Morphine and Tranylcypromine: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.

معنای این تداخل به زبان ساده

Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Morphine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

Irreversible MAO inhibition potentiates serotonergic and CNS depressant effects of the opioid.

اقدام لازم

Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Morphine و Tranylcypromine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Morphine with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.

How serious is the interaction between Morphine and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.

What other medicines interact with Morphine?

MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.

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